Journal article
Metabolic response to preoperative chemotherapy predicts prognosis for patients undergoing surgical resection of colorectal cancer metastatic to the liver
LF Lau, DS Williams, ST Lee, AM Scott, C Christophi, V Muralidharan
Annals of Surgical Oncology | Published : 2014
Abstract
Background: Biological characteristics of colorectal cancer liver metastases (CRCLM) are increasingly recognized as major determinants of patient outcome. The purpose of this study was to evaluate the prognostic value of metabolic response to preoperative chemotherapy as quantified by 18F-FDG positron emission tomography (PET) for patients undergoing liver resection of CRCLM. Methods: All patients (n = 80) who had staging PET before liver resection for CRCLM at Austin Health in Melbourne between 2004 and 2011 were included. Thirty-seven patients had PET and CT imaging before and after preoperative chemotherapy. Semiquantitative PET parameters - maximum standardized uptake variable (SUVmax), ..
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Awarded by Royal Australasian College of Surgeons
Funding Acknowledgements
The authors gratefully acknowledge Roger Berry, Michael Fink, Mehrdad Nikfarjam, Robert Jones, and Graham Starkey from the Hepato-Pancreato-Biliary and Transplant Unit at Austin Hospital, Mark Goodwin from the Department of Radiology, Niall Tebbutt from GI Oncology, and the staff of the Centre for PET, Austin Hospital, for their contribution to this study. This study was supported in part by the Royal Australasian College of Surgeons Eric Bishop Scholarships and Royal Australasian College of Surgeons Raelene Boyle Scholarships, NHMRC Program Grant 487922, and OIS funding from the Victorian Government.